[An evaluation of the role of paired loading tests in selecting the long-term drug therapy for patients with stable angina]. / Otsenka roli parnykh nagruzochnykh testov v podbore dlitel'noi medikamentoznoi terapii bol'nym so stabil'noi stenokardiei.

The examination of 208 patients with stable exercise-induced angina has demonstrated that the long-term (12 weeks and 12 months) antianginal effect can be predicted with a high accuracy from the results of acute pair exercise test using the drugs. The negative result of the test with verapamil is not informative due to the accumulation of its antianginal effect when the agent is used long. The long-term antianginal effect of nitrosorbide is determined not only by positive pair exercise test, but mainly by its dosage regimen during a day. The fact that half the patients who took labetalol for a long time developed tolerance to its anginal effect casts some suspicion on the advisability of its administration in stable angina. Lipid peroxidation as a mechanism of platelet aggregability regulation.

[Anti-anginal effect of long-term use of obsidan, corinfar and finoptin in patients with stable exercise-induced stenocardia]. / Antianginal'nyi éffekt dlitel'nogo primeneniia obzidana, korinfara i finoptina u bol'nykh so stabil'noi stenokardiei napriazheniia.

Time course changes in antianginal effect were evaluated for obsidan, corinfar and finoptin under 12-week administration in 104 patients with stable angina pectoris. The response to finoptin appeared to rise while for obsidan and corinfar it was stable. Some patients with stable angina developed clinical tolerance to corinfar.

[Mechanisms of the anti-anginal effect of korinfar]. / K voprosu o mekhanizmakh antianginal'nogo éffekta korinfara.

Some clinical, hemodynamic and biochemical parameters were studied in 25 patients with ischemic heart disease of II-III functional classes depending on the presence of the antianginal effect during paired loading pharmacodynamic tests with corinfar. The antianginal effect of corinfar was found to be associated with a marked growth of "double product" and the presence of a clinical symptom of adaptation. In patients with the lack of corinfar antianginal effect there were noted the adaptation symptom absence and a higher blood catecholamine level. A decrease of the postloading did not correlate with the drug antianginal effect. The data could indicate that in the mechanism of corinfar antianginal effect the determining factor is its direct influence on the coronary circulation.